In apoptotic cells, there should generally be a lack of mitochondrial abnormalities,
increased lysosomal or autophagocytic profiles, or major abnormalities
of the endoplasmic reticulum or Golgi apparatus.
1-4
In other words, the
cytoplasm should appear relatively normal, although condensed in volume
and electrondense. In necrosis, swollen abnormal mitochondria and abnormal
cytoplasmic features make the cell look abnormal even at low power
with swollen and electron-lucent appearance.