In Brief
Purkinje cell simple spike suppression is
a central driving mechanism in cerebellar
conditioning. Here, ten Brinke et al. show
how simple spike suppression,
conditioned stimulus-related complex
spikes, and molecular layer interneuron
(MLI) activity correlate to conditioned
eyelid behavior. Moreover, transgenic
impairment of MLI input results in deficits
in conditioned behavior.