In the present study, we show that seed oil from pomegranate has a stimulatory effect on keratinocyte proliferation but does not stimulate dermal fibroblast function. In contrast, an aqueous extract of pomegranate peel has a potent dermal effect—stimulating dermal fibroblast proliferation and collagen synthesis while inhibiting the major collagen-degrading enzyme in skin—but does not stimulate keratinocyte proliferation.