The immobilisation of Chinook salmon digestive lipase on a hydrophobic resin demonstrates a potential route for industrial application of this fish lipase. There are some barriers to overcome before this system could be used successfully in a commercial setting. In this study, Toyopearl Butyl-650C was used as the model hydrophobic support but this is too costly and the particle size too fine for practical industrial use. A resin support is needed that is economical yet delivers the desired binding and activity characteristics along with food-grade cleaning regimes that do not cause activity loss. Despite the raw material (pyloric ceca) being both cheap and abundant, there are significant costs associated with developing large-scale, food-grade extraction and immobilisation processes. The technique used here, where the lipase is immobilised directly from a crude extract (with potential for concurrent extraction of the proteases) perhaps even in the reactor, goes some way towards a commercially viable process. Acknowledgements