The above literature shows that we are not fairly well informedof the prevalence of depression and its associated factors withinthe Ghanaian context. We aimed to assess the prevalence ofdepressive symptoms and to describe the determinants among asample of university students in Ghana. The main research questions examined are: (1) what is the prevalence of depressionamong university students? and (2) what factors are associatedwith depression among university students in, Ghana? The findings of this study could inform interventions that could targetuniversity students who could be at risk for depressive symptoms.