pharmaceutical analysis such as butyrolactone determination employing glass electrode for end-point detection [12]. Some organic and pharmaceutical compounds were analyzed by electrogenerating gold(III) and biamperometric end-point detection [13]. CO2 in water could be rapidly determined by coulometric titration [14]. Coulometric titration has been incorporated in flow analysis, also with various end-point detection systems including spectrophotometric (for acid–base) [15], potentiometric (for ascorbic acid determination) [16] and [17].