Quality of life (QOL) and pain were prospectively assessed in 105 patients treated for LRRC at a single-institution, using the validated the Functional Assessment of Cancer Therapy- Colorectal (FACT-C) and Brief Pain Inventory (BPI) questionnaires. In 54 patients enrolled and followed from diagnosis of LRRC, relationship between pre-treatment pain, QOL and overall survival (OS) were examined.