Recently, much attention has been focused on personal glucose meter (PGM). PGM is usually used to detect the glucose concentration of diabetic patients
it has the characteristics of low cost, simple operation and portability
It can be obtained in stores with only $10 for a meter, which can be integrated into cell phones for point-of- use. Therefore, PGM is a worldwide commercial availability to the public. However, the PGM is still limited in that it can detect only a single target, glucose. In 2011, Lu linked PGM with functional DNA sensors to achieve portable, low-cost and quantitative detection of targets beyond glucose.
Yi Lu introduced DNA–invertase conjugates to a magic bead, by using a sandwich assay method, DNA can be portably and quantitatively detected. However, only a detection limit of about 40pM was obtained, which was relative higher for ultralow detection of cancer related DNA molecules (Xiang and Lu, 2012). New strategies are needed to improve the sensitivity of PGM sensor.