AV severity assessed by number of acne lesions The numbers of AV lesions before and after treatment are showed in Table 2. Overall, reduction of total lesion was higher in treated compared to control group, 37 vs 27% (p < 0.05). The reduction of non-inflamed lesions (comedos) was higher (63%) than inflamed (papules + pustules) lesions (35%) after three weeks treatment with mangosteen extracts (p < 0.05).