Mushroom spores can cause respiratory allergic dis-
eases such as asthma and hypersensitivity pneumonitis
(HP), and these disorders have been increasing in recent
years (1^7). Hypsizigusmarmoreus, called`Bunashimeji' in
Japanese, is one of the common edible mushrooms. As
cultivation takes place indoors, when they are fully
grown, the cultivating, harvesting and packing rooms
are ¢lled with the mushroom spores, because Bunashi-
meji is `open' very early and releasing spores well before
harvest. The size of the Bunashimeji spores is 4 ^6 mm