We are currently evaluating the use of Halobacteriovorax to inactivate V. parahaemolyticus in a modified oyster depuration process with the ultimate goal of designing processing interventions capable of inactivating a host of bacterial pathogens, including V. parahaemolyticus, V. vulnificus, E. coli, and Salmonella spp., in shellfish. The prospect of isolating Halobacteriovorax against an unlimited number of Gram-negative pathogens may permit the development of broad-based biocontrol technologies to enhance the safety of commercially marketed shellfish and other foods.