With the short reproduction time of these insects, and their genetic ability to evolve resistance to poisons, the scientists are urging less reliance on chemicals as a means of control.
"We need to emphasis that we need to use different tools - we can't depend totally on chemicals we need to incorporate other alternatives," said Dr Romero.
"The pest control industry are incorporating new tools, heat, vapour, encasement, there are a bunch of these non-chemical methods that definitely help."
The scientists recognise and even admire the evolutionary ability of these creatures to rapidly overcome humanity's attempts to control them.
Dr Romero says the latest research indicates that the bugs are unlikely to be effectively controlled by chemical means in the near future.
"It's a very complex problem and we are going to have bed bugs for many years because of this problem with insecticides and then there is a social context that makes eradication and control very difficult."
The paper has been published in the Journal of Medical Entomology.