There are several potential disadvantages of ion-selective electrodes,
as compared to standard analytical methods. One is chemical
interference by other ions because ion-selective electrodes are
not truly specific but respond more or less to a variety of interfering
ions. To overcome interference issues, various data processing
methods have been used. For example, multivariate calibration
models have been proposed to allow cross responses arising from
primary and interfering ions to be decoupled, thus allowing accurate
determination of individual ion concentrations within mixtures
(Forster et al., 1991). In some cases, another compound can
be added to suppress the interference effect. For example, Ag2SO4
can be used to suppress the chloride interference in nitrate sensing
(Van Lierop, 1986).
There are several potential disadvantages of ion-selective electrodes,as compared to standard analytical methods. One is chemicalinterference by other ions because ion-selective electrodes arenot truly specific but respond more or less to a variety of interferingions. To overcome interference issues, various data processingmethods have been used. For example, multivariate calibrationmodels have been proposed to allow cross responses arising fromprimary and interfering ions to be decoupled, thus allowing accuratedetermination of individual ion concentrations within mixtures(Forster et al., 1991). In some cases, another compound canbe added to suppress the interference effect. For example, Ag2SO4can be used to suppress the chloride interference in nitrate sensing(Van Lierop, 1986).
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