c-Myc is an oncogene that can promote tumorigenesis in many normal
tissues. Elevated c-Myc in tumor cells induces changes in cell proliferation, cell adhesion, apoptosis, and angiogenesis [10,15].
Among 14 botanical extracts, baicalein exhibit the strongest inhibitory
effect on c-Myc expression in HCC cells, suggesting an anticancer potential.
It has been reported that inactivated c-Myc uncovers the pluripotent
capacity of tumor cells to differentiate into normal cellular
lineage [8].