Skin diseases such as dermatitis, prurigo, and scabies present a major health concern in the Eastern Cape, South
Africa,where there is a scarcity of dermatologists, compounded by the fact thatmost dermatologists are centered
near urban areas and are not accessible to 70% of the rural population. Hence,many people still depend to a large
extent on traditional herbs such as Citrus limon for the treatment of skin diseases. The aim of this studywas therefore
to screen the acetone and ethanol extracts of C. limon for its antioxidant potential and antimicrobial efficacy
agents against a panel of microbes implicated in skin diseases. The highest antibacterial activity was obtained
with the acetone extract of C. limon against Enterococcus faecalis and Bacillus subtilis, and the most susceptible
bacteria based on the overall mean inhibition diameters were the gram-negative Salmonella typhimurium,
Shigella sonnei and the gram-positive E. faecalis and B. subtilis. Both extracts were active against Candida glabrata.
The DPPH scavenging activity of the acetone extract was not significantly different from those of vitamin C and
rutin. Nitric oxide scavenging activity was lowest in the ethanol extract of C. limon. The reducing ability of both
plant extracts was significantly lower than that of vitamin C and rutin. The fact that both extracts of C. limon
exhibited a broad spectrum of antibacterial activity and comparable efficacy to the synthetic antioxidants highlights
the medicinal value of C. limon as a potential source for drug development amidst the obvious dearth of
effective and safe antibacterial drugs, and also validates the ethnotherapeutic claim of the plant.
© 2015 SAAB. Published by Elsevier B.V. All rights
Skin diseases such as dermatitis, prurigo, and scabies present a major health concern in the Eastern Cape, SouthAfrica,where there is a scarcity of dermatologists, compounded by the fact thatmost dermatologists are centerednear urban areas and are not accessible to 70% of the rural population. Hence,many people still depend to a largeextent on traditional herbs such as Citrus limon for the treatment of skin diseases. The aim of this studywas thereforeto screen the acetone and ethanol extracts of C. limon for its antioxidant potential and antimicrobial efficacyagents against a panel of microbes implicated in skin diseases. The highest antibacterial activity was obtainedwith the acetone extract of C. limon against Enterococcus faecalis and Bacillus subtilis, and the most susceptiblebacteria based on the overall mean inhibition diameters were the gram-negative Salmonella typhimurium,Shigella sonnei and the gram-positive E. faecalis and B. subtilis. Both extracts were active against Candida glabrata.The DPPH scavenging activity of the acetone extract was not significantly different from those of vitamin C andrutin. Nitric oxide scavenging activity was lowest in the ethanol extract of C. limon. The reducing ability of bothplant extracts was significantly lower than that of vitamin C and rutin. The fact that both extracts of C. limonexhibited a broad spectrum of antibacterial activity and comparable efficacy to the synthetic antioxidants highlightsthe medicinal value of C. limon as a potential source for drug development amidst the obvious dearth ofeffective and safe antibacterial drugs, and also validates the ethnotherapeutic claim of the plant.© 2015 SAAB. Published by Elsevier B.V. All rights
การแปล กรุณารอสักครู่..
