In total, 188 clones showed differential expression in both 6 and 12 HPC-WSSV and Vibrio samples. Most of the differentially expressed genes (185/188) were down-regulated in the samples of 12 h post WSSV challenge, whereas some genes were up-regulated in the samples at 6 h and 12 h post Vibriochallenge and 6 h post WSSV challenge.