Apolipoprotein E plays a major role in systemic
cholesterol metabolism by serving as a ligand for the
removal of cholesterol-laden plasma lipoproteins by hepatic
receptors. In the present study, the plasma concentration of
apo E was not affected by the diet. The liver total and
esterified cholesterol concentrations were also not affected
by the diet. Kim et al [40] showed that dietary fat saturation
does not differentially alter the hepatic apo E mRNA
concentration in rats.