The lethal phenotype of Ang2 transgenic mice suggests that elevated circulating ANG2 levels are potentially harmful. however, it is not clear if systemically elevated ANG2 is just a marker of EC activation or if it actively contributes to endothelial pathology. It is noteworthy that women have elevated circulating levels of ANG2 during the first trimester of
pregnancy, which might reflect the intense placental vascular remodelling process that takes place during this
period