The packed distillation column used, in a laboratory scale,was satisfactory for the separation, promoting the enrichment of the ethanol in all the systems investigated. The higher enrichment was reached when the different salts were added,although the acetates had demonstrated better performance. The use of the original charge from the ethanol plant, known as load of wine, confirmed the affirmation about the performance of the acetates and corroborated that the calcium chloride was the salt that had the better behavior. This salt deserves more attention for future researches because it is cheaper than the others. The mixture of acetates had a similar performance, as cited by the literature, although it had a lower saline effect than the potassium acetate alone. The higher solubility of that salt can justify the better hydration obtained due to the fact that the salt tends to be associated with the water, which is more polar than ethanol. The thermodynamic model well correlated the data with different concentration of salts and predict the behavior that was observed during the separation in the packed column.