Although most of the literature is consistent with the view that Ginkgo
biloba leave extract can protect against the effects of neural damage, whether
the neuroprotection is from a direct action on the neurons or from an indirect
effect from modulation of blood flow and antioxidant action is unclear (24).
Krieglstein and coworkers (25) determined that in rodents, both bilobalide and
ginkgolides A and B reduced the infarct area on the mouse brain surface when
administered before occlusion. When Ginkgo biloba leave extract was injected
into rats after global forebrain ischemia, local cerebral blood flow was significantly
elevated, but neuroprotection was not observed (26)