Besides the imaging ellipsometry, a series of related techniques have been developed for the biosensor, which
mainly includes the surface pattern fabrication of a protein microarray [4], the various ligand oriented immobilization,
the samples delivery, the biomolecule affinity presentation, the specific interaction, the prevention of unspecific
binding, as well as the realization of the detection sensitivity of 0.1 ng/mL for immunoglobulin, the sample
consumption about 10 L, the sampling and calibration for quantification, etc. It has been developed into an automatic
analysis technique for protein detection. A 48 independent channel throughput protein analysis as shown in Fig. 1. Its
principle, methodology, related techniques, especially how to realize the biosensor system [5] and its biomedical
applications [6, 7] is presented in this repor