Most studies in the field are restricted to short-term effects of sugars on
energy metabolism and other parameters. In the majority of cases
the study designs are variable, and type (e.g. fructose versus
glucose) and texture (liquid versus solid form) of the sugars are
hardly analyzed in detail [7,8,23].
The aim of the present study was to investigate the influence of
type and texture of dietetic sugars in mice. We fed liquid and solid
high-fructose and -sucrose diets, and analyzed their influence on
feeding behavior as well as the development of obesity and fatty
liver disease. In obese and lean humans, intestinal sugar
transporter and weight regulating hormone expression was
analyzed.