Wound healing involves coordinating connective tissue repair, angiogenesis and re-epithelialization, in response to injury or trauma (36). The result is the formation of nascent tissue, fibroblast proliferation and the secretion of extracellular matrix proteins and growth factors (27,37). It has been widely established that the role of angiogenesis is crucial during would healing. This process primarily supplies oxygen, as well as metabolites, to the newly formed tissues and works to remove any damaged and waste products of the metabolism during the repairing process (38). Furthermore, angiogenesis may be responsible for regulating processes involved in wound healing, indicated by the fact that impairment of angiogenesis causes wound healing to be impaired or unsuccessful (39). In addition, angiogenesis provides 60% of newly formed blood vessels with relevant repairing molecules and as such neovascularization would help in attaining normoxic conditions in hypoxic wounds (40).