A scientific explanation for this behavior is not clear and it is
not described in the literature. The above mentioned cases show
thatlower pressures improve the extraction yield using co-solvents
[7,14,15,39]. But other authors reported that high pressures effi-
ciently enhanced fluidity extractions using different raw materials,
such as aloe vera leaf skin, chamomile, grape seed or marigold [18].
Moreover, in some cases the modifier has little or no effect on the
global yield but improves the extract composition with respect
to bioactive compounds. Therefore, the effect of pressure on the
extraction process using co-solvents possibly depends on the type
of matrix and the interactions solute–matrix.