this chip was not applicable for the process of fully drawing blood in a clinical setting, typically 7.5 mL. Before injecting the blood samples into the GASI chip, the cells were preconcentrated into 1–2 mL of buffer by conventional centrifugation to handle the large sample volume, but the capture efficiency with a high concentration of cells decreases because the captured cells tend to detach by interaction with cells traveling in the flow stream (Sin et al., 2005). Additionally, although this chip can isolate heterogeneous CTCs, the cells need to be sorted based on their characteristics to investigate their heterogeneity.