In vivo studies showed a significant decrease in markers of EC/vascular cell
activation and/or inflammation in visceral adipose tissue (VAT), thoracic aorta, and heart collected from nanoSOD-treated mice compared to obese control mice. Interestingly, the expression of metallothionein 2, an antioxidant gene was significantly increased in nanoSOD-treated mice. Conclusion. Our data show that nanoSOD is very effective in delivering active SOD to ECs and in reducing EC oxidative stress.