Although melatonin holds promise, its routine use is not recommended. In one study patients taking both melatonin
and nifedipine were found to have poorer blood pressure
control than the control group, yet no relevant adverse effects
were found in other reviews concerning melatonin in
elders.13 Also, like herbal preparations, melatonin is a nutritional
supplement with variable formulations at particular
dosages. Questions regarding the therapeutic use of
melatonin, such as optimal dosage, long-term effects, and
drug interactions, still require further investigation.