Our review confirms a shortage of RCTs in EOS, and also reveals a decreasing trend in publishing head-to-head RCTs. Since 2008, only one head-to-head RCT has been published.14 This might be associated with the disappointment arising from the premature termination of the olanzapine arm in the McClellan et al study (due to weight gain), which skewed the results of the entire study.12 In contrast, numerous comparative head-to-head studies have enabled extensive meta-analyses that have provided important information concerning the treatment of schizophrenia in adult populations