Neurologic Complications
A temporal and geographic relationship has been observed between Guillain–Barré syndrome and Zika virus outbreaks in the Pacific and the Americas.19,21,72-74 In the outbreak in French Polynesia, 38 cases of Guillain–Barré syndrome occurred among an estimated 28,000 persons who sought medical care.19 A case–control study in French Polynesia revealed a strong association (odds ratio, >34) between Guillain–Barré syndrome and previous Zika virus infection; the findings from electrophysiological studies were compatible with the acute motor axonal neuropathy subtype of Guillain–Barré syndrome.75 Meningoencephalitis76 and acute myelitis77 complicating Zika virus infection also have been reported.