In their systematic review and meta-analysis, McDonald et al.
[6] identified 7 papers reporting on a total of 273 patients with
preeclampsia and less than 100 events of microalbuminuria.
Despite the limited numbers, they found evidence of an increased
risk of microalbuminuria following preeclampsia {pooled risk ratio
of 4.3 (95% CI 2.7, 6.9)} but there was considerable heterogeneity
among the included studies and a strong possibility of publication
bias. There was, however, no difference in terms of serum creatinine levels and estimated Glomerular Filtration Rate (eGFR)
between women with preeclampsia and those without. An
updated search of the literature identified three additional papers
[7–9] all reporting a positive association between preeclampsiaand long term kidney damage, although heterogeneity in terms of
exposure and outcome measurement remained as did the possibility of publication bias. In their review, McDonald et al. [6] called for
further research investigating the persistence of microalbuminuria
following preeclampsia in larger population based studies,
taking into consideration confounding factors such as age, BMI,
smoking etc.