Acute cardiac dysfunction
Acute cardiac dysfunction can contribute in weaning
failure. Airway obstruction and dynamic hyperinflation
in mechanically ventilated COPD patients can increase
preload by increasing venous return. Patients with
occult cardiac dysfunction cannot tolerate this additional
load and can lead to the development of cardiogenic
pulmonary edema during weaning of difficult‑to‑wean
COPD patients.[13] Weaning also results in increase in
afterload, which is more prominent in patients with