allergy immunotherapy with native allergens
allergy immunotherapy (AIT), introduced by noon and free-man about a century ago, has been an important therapeutic strategy in reducing symptoms and drug consumption in allergic diseases. AIT acts reducing th2 and stimulating th1 reaponse through regulatory T cell. these cells inhibit allergic inflammation through IL-10 and TGF- release. IL-10 shifts allergen specific ige in igG4, while TGF- increases allergen specific iga levels. therefore ait reduces seasonal production of ige and increases protective allergen specific igg4.