For many people, allergies are a seasonal annoyance. But for others, exposure to a particular allergen can cause adverse reactions such as itching, breathing problems or even death. Allergy shots can reduce sensitivity by slowly ramping up exposure to the offending substance. But because these shots expose the body to the very thing people are allergic to, the treatment itself can sometimes trigger reactions. In order to develop a safer, more direct, cause-based therapy, researchers have developed nanoparticles that envelop an allergen and deliver it to specific cells. But these carriers degrade too slowly, hampering the effectiveness of the treatment. Holger Frey and colleagues set out to overcome these limitations.