Paracetamol is safe in patients with chronic liver disease but a reduced dose of 2-3 g/d is recommended for long-term use.
Non-steroidal anti-inflammatory drugs (NSAIDs) are best avoided because of risk of renal impairment, hepatorenal syndrome, and
gastrointestinal hemorrhage. Most opioids can have deleterious effects in patients with cirrhosis. They have an increased risk of toxicity
and hepatic encephalopathy. They should be administrated with lower and less frequent dosing in these patients and be avoided in
patients with a history of encephalopathy or addiction to any substance.