Aspirin is given initially in an antiinflammatory dosage (80 to 100 mg/kg/day in divided dose every 6 hours) to control fever and symptoms of inflammation. The duration of therapy varies among institutions. Once fever has subsided and the child has been afebrile for 48 to 72 hours, the aspirin dosage is generally decreased to an antiplatelet dosage (3 to 5 mg/kg/day). Low-dose aspirin therapy is continued in patients without echocardiographic evidence of coronary abnormalities until the platelet count has returned to normal (6 to 8 weeks). If the child develops coronary abnormalities, low-does (antiplatelet) salicylate therapy is continued indefinitely. Additional anticoagulatory therapy, such as warfarin administration, may be indicated in children with giant aneurysms (laeger than 8mm), who are at the greatest risk for morbidity and mortality (Newburger, Takahashi, Gerder, and other, 2004). International normalized ratio levels are maintained at 2.0 to 2.5 in these patients.