It is not clear whether HIV infection increases the risk of acquisition of vaginal infections, but these conditions are common among sexually active women. Sexually transmitted infections (STIs) and preinvasive cervical lesions were found to be more prevalent among HIV-infected pregnant women compared to their noninfected counterparts [1]. Even comparing African and USA cohorts, HIV pregnant patients present a higher prevalence of vaginal infections compared to HIV seronegative. Women with positive vaginal cultures had slightly higher rates of infectious morbidity than those without (20.5% versus 15.2%, ). Trichomonas vaginalis and Group B Streptococcus were significantly associated with sepsis. There is some evidence of possible benefits due to the identification and treatment of vaginal intercurrent infection in HIV-positive patients. Perinatal mortality has not been affected, but some reduction in amnionitis in case of membrane rupture has been demonstrated