Minamata disease caused by mercury poisoning. The symptoms of malnutrition. There is a mild psychotic symptoms screaming black eyes widened slightly dry tongue but could not find the cause of the malfunction. Difficulty moving limbs A stiff jerky Limbs twisted violently. Because this disease affects the central nervous system. This disease was first discovered in Minamata. Japan on May 1, 2499 as a result of the disposal of wastewater containing mercury out.