Seventy percent of CMPA patients in
our study were male with a mean age at diagnosis
of 8 months and mean age of onset of 3 months.
The reaction time to CM ranged from within 7
minutes to within 14 days. Positive IgEsensitization
was defined as either a specific IgE
to CM of more than 0.35 kUA/L (N=11) or SPTs
positive for CM and/or fresh cow milk (N=20).
Forty-eight percent of the patients (n = 13) could
tolerate CM by 13.38 months (8 – 19 months).
Mean specific-IgE levels to CM were 4.1 kUA/L
(range 0.35 – 14.3 kUA/L). Determination of the
cytokine (IL-10, IFN-γ, IL-5) response to BLG
revealed significantly higher IL-10 levels during
the tolerance phase (212.93 vs 142.46 pg/ml, P =
.011). There was a significant increase in BLGIgG4
and the BLG-IgG4/IgE ratio in the tolerance
phase when compared to the symptomatic phase.