The immune therapeutic efficacy of this approach was further
improved in a small trial of triple-combination
therapy with DNA vaccination encoding the
WHcAg and WHsAg, programmed death-ligand 1
blockage and antiviral treatment. This treatment
resulted in sustained immunological control of viral
infection, generation of specific antibodies and
complete viral clearance (with undetectable levels
of cccDNA in the liver) in one out of three animals
tested