Preemptive dosing to time the peak pharmacodynamic effect of IV acetaminophen to optimize analgesic effectiveness has been studied clinically. For example, in a study of patients undergoing total abdominal hysterectomy, IV acetaminophen 1 g administered 30 minutes prior to surgical incision (prior to induction) resulted in a greater reduction in total morphine consumption compared with administering the same dose at the end of surgery just prior to skin closure