Vascular closure devices, when compared with the mechanical C-clamp and manual compression, all provide low and comparable complication risks following sheath removal in the era of antiplatelet and antithrombotic therapies.3,72 Appropriate selection of patients by the physician is important, and the device should be placed only after confirmation of the vascular anatomy and the absence of significant local peripheral arterial disease. In cases in which vascular closure devices are not effective, manual compression must be applied to accomplish hemostasis.