Ghrelin has emerged as the first identified circulating hunger hormone Ghrelin is both a hormone in the endocrine system and a neurotransmitter in the nervous system 28 amino-acid polypeptide Secreted by oxyntic cell in gastric fundus Can be found in pancrease, intestine, hypothalamus, pituitary gland
4. Introduction2 Ghrelin is produced mainly by P/D1 cells, lining the fundus of the human stomach, that contain granules filled with ghrelin Also by epsilon cells of the pancreas that stimulates hunger In rodents, X/A-like cells produce ghrelin. Aside from the stomach and pancreas in adults, ghrelin cells are also found in the duodenum, jejunum, i leum, and colon, with ghrelin concentration decreasing from the duodenum to the colon.