RNA sequence data in dicate that the dengue viruses are evolving and diverging .The molecular basis of virulence and pathogenesis of DHF/DSS must be better understood, to ensure that vaccine development stays ahead of dengue virus evolution. The mechanisms of vaccine-induced protection need to be clarifie in future fiel trials. The consensus immunogenic target of a neutralizing antibody response to all 4 serotypes in at least 80% of volunteers may not be appropriate in all populations and clinical settings.
RNA sequence data in dictated that the dengue viruses are developing and diverging .The molecular basis of virulence and pathogenesis of DHF/DSS must be better understood, to approve that vaccine development stays ahead of dengue virus evolution. The mechanisms of vaccine-induced protection need to be clarified in future. The consent immunologic target of a neutralizing antibody response to all 4 serotypes in at least 80% of volunteers may not be reasonable in all populations and clinical settings.