Control Applications: Depending on the provided information (from the big data center component) combined with the clin-icians’ and specialists’ medical knowledge (from the healthcare systems component), the clinician in the observation center may decide to send some decisions to the control/actuation component, which could involve invoking an alert/reminder, informing a care giver, or configuring a smart device. Finally, necessary measures will be conducted on the patients based on the invoked control applications.