Kaempferol is a polyphenol antioxidant found in fruits and vegetables.Many studies have described the beneficial
effects of dietary kaempferol in reducing the risk of chronic diseases, especially cancer. Epidemiological
studies have shown an inverse relationship between kaempferol intake and cancer. Kaempferolmay help
by augmenting the body’s antioxidant defence against free radicals, which promote the development of cancer.
At the molecular level, kaempferol has been reported to modulate a number of key elements in cellular
signal transduction pathways linked to apoptosis, angiogenesis, inflammation, andmetastasis. Significantly,
kaempferol inhibits cancer cell growth and angiogenesis and induces cancer cell apoptosis, but on the other
hand, kaempferol appears to preserve normal cell viability, in some cases exerting a protective effect. The aim
of this review is to synthesize information concerning the extraction of kaempferol, as well as to provide
insights into themolecular basis of its potential chemo-preventative activities, with an emphasis on its ability
to control intracellular signaling cascades that regulate the aforementioned processes. Chemoprevention
using nanotechnology to improve the bioavailability of kaempferol is also discussed.
Kaempferol is a polyphenol antioxidant found in fruits and vegetables.Many studies have described the beneficialeffects of dietary kaempferol in reducing the risk of chronic diseases, especially cancer. Epidemiologicalstudies have shown an inverse relationship between kaempferol intake and cancer. Kaempferolmay helpby augmenting the body’s antioxidant defence against free radicals, which promote the development of cancer.At the molecular level, kaempferol has been reported to modulate a number of key elements in cellularsignal transduction pathways linked to apoptosis, angiogenesis, inflammation, andmetastasis. Significantly,kaempferol inhibits cancer cell growth and angiogenesis and induces cancer cell apoptosis, but on the otherhand, kaempferol appears to preserve normal cell viability, in some cases exerting a protective effect. The aimof this review is to synthesize information concerning the extraction of kaempferol, as well as to provideinsights into themolecular basis of its potential chemo-preventative activities, with an emphasis on its abilityto control intracellular signaling cascades that regulate the aforementioned processes. Chemopreventionusing nanotechnology to improve the bioavailability of kaempferol is also discussed.
การแปล กรุณารอสักครู่..
