D.radiodurans nucleoids adopt a condensed structure that remains unaltered after high-dose gamma-radiation. The tightly compacted structure of the nucleoid may prevent the diffusion of DNA fragments generated by many DNA-damaging agents and contribute to radio and oxidative resistance in these species. Bacterial NAPs play a central role in nucleoid organization, DNA compaction and gene regulation. In this work, we evaluated the role of DR0199, a histone-like protein, in DNA damage tolerance of D. radiodurans.