Solvent dispersion method
Ether injection (solvent vaporization) A solution of
lipids dissolved in diethyl ether or ether-methanol mixture
is gradually injected to an aqueous solution of the
material to be encapsulated at 55°C to 65°C or under
reduced pressure. The consequent removal of ether
under vacuum leads to the creation of liposomes. The
main disadvantages of the technique are that the population
is heterogeneous (70 to 200 nm) and the exposure
of compounds to be encapsulated to organic solvents at
high temperature .