The issue of the localization of tremor generators remains central in the field of tremor research . The selection of the sensor helps in improving (1) our understanding of the respective contributions of supra-spinal and spinal structures, and (2) how the state of the neuromuscular periphery influences tremor. Using sensors that do not significantly impede wrist movements (so-called ‘soft’ tremor sensors) and more rigid sensors (approximating the condition to isometric), it has been shown that the fixation of a wrist joint decreases the amplitude of tremor bilaterally with a relatively low impact on tremor frequency suggesting an important role for the neuromuscular and spinal cord mechanisms in determining tremor amplitude. This is an example of how mechanical properties of a sensor influence results and interpretation of the mechanisms of tremor.