General methodology according to the Appraisal of Guidelines for Research and Evaluation (AGREE) II
framework and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system.
Systematic evidence-based review according to Preferred Reporting Items for Systematic Reviews and Meta-
Analyses (PRISMA) methodology, based upon relevant clinical questions with respect to patient-important
outcomes, including Quality Assessment of Diagnostic Accuracy Studies (QUADAS) and Centre of Evidence Based
Medicine (CEBM) quality ratings. Based upon the results, GRADE recommendations, guidelines and discharge
instructions were drafted. A modified Delphi approach was used for consensus and relevant clinical stakeholders
were consulted