Discussion
This study represents the first randomized aspirin trial,
and a novel therapeutic approach, in the treatment of
established colorectal cancer. The failure of 3 large
randomized trials to show benefit for irinotecan in the
adjuvant treatment of colorectal cancer and the recent
disappointing failure of anti-VEGF and anti-EGFR
monoclonal antibodies to improve survival makes the
search for effective new agents all the more urgent